What word is associated with a feeling of discomfort or unease?

Malaise is a term specifically associated with a general feeling of discomfort, unease, or dissatisfaction. It often describes a condition where an individual feels unwell or is experiencing a vague sense of pain or discontent, which can stem from both physical and psychological sources. The root of malaise relates to the dissatisfaction that can accompany various health issues or emotional states, making it a fitting descriptor for the sensation of unease.

In contrast, the other terms represent more positive or different emotional states. Ecstasy and elation convey feelings of intense happiness or joy, while despondence indicates a state of low spirits or a sense of hopelessness, which is distinct from the broader discomfort signified by malaise. Thus, malaise is the most accurate choice when describing the feeling of discomfort or unease.